Bisphosphonates inhibit surface‐mediated osteogenesis
نویسندگان
چکیده
منابع مشابه
Oral bisphosphonates for paediatric osteogenesis imperfecta?
www.thelancet.com Published online August 6, 2013 http://dx.doi.org/10.1016/S0140-6736(13)61531-7 1 Children and adolescents with osteogenesis imperfecta have numerous fractures, often after what would otherwise seem trivial trauma. Even in mild disease, the risk of breaking a long bone (femur, tibia, fi bula, humerus, radius, or ulna) is about 100 times higher than in the general population. A...
متن کاملExperience with bisphosphonates in osteogenesis imperfecta.
Until recently, medical management of osteogenesis imperfecta, a genetic disorder of reduced bone mass and frequent fractures, was elusive, and treatment was focused on maximizing mobility and function. The introduction of bisphosphonates for the treatment of osteogenesis imperfecta 14 years ago changed this paradigm. Cyclic intravenous pamidronate therapy leads to an increase in bone density a...
متن کاملFemoral neck fractures in osteogenesis imperfecta treated with bisphosphonates
PURPOSE Osteogenesis imperfecta (OI) is a condition characterised by bone fragility and multiple fractures, which cause considerable morbidity in the affected patients. Most cases are associated with mutations in one of the type I collagen genes. Recently, bisphosponates have been used widely to reduce pain and the incidence of fragility fractures in OI in children, even though there have been ...
متن کاملBisphosphonates, osteonecrosis, osteogenesis imperfecta and dental extractions: a case series.
Over the past 4 years, numerous cases of osteonecrosis of the jaw in patients treated with bisphosphonates have been reported. Since 1998, children and adolescents with osteogenesis imperfecta have received bisphosphonates to increase their bone density and reduce the incidence of bone fractures. The results have been convincing, but recent reports of osteonecrosis of the jaw have caused great ...
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+*Koto, K; *Murata, H; *Sakabe, T; *Matsui, T; *Horie, N; *** Kimura, S; ***Maekawa, T; **Fushiki, S; *Kubo, T + *Department of Orthopaedics, Graduate School of Medical Science. Kyoto Prefectural University of Medicine, Kyoto, Japan **Department of Pathology and Applied Neurobiology, Graduate School of Medical Science. Kyoto Prefectural University of Medicine, Kyoto, Japan ***Department of Tran...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2020
ISSN: 1549-3296,1552-4965
DOI: 10.1002/jbm.a.36944